AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |
Back to Blog
Jing xu md11/12/2023 ![]() ![]() CHPD, also known as antimicrobial peptides, are endogenous peptides that modulate hosts’ immune responses to control infection and inflammation. We have also established a panel of proteins that are significantly elevated in the joint tissues of CIA mice, which includes cationic host defence peptides (CHDP), specifically cathelicidin CRAMP and calprotectin (S100A8 and S100A9). We showed that Cureit™ curcumin (CUR) delays disease onset and decreases clinical symptoms and the abundance of circulating inflammatory cytokines, in the CIA mice. In a previous study, we demonstrated the beneficial effects of a highly bioavailable form of curcuminoid formulation (Cureit/Acumin™) in a collagen-induced arthritis (CIA) mouse model. However, a major challenge in its use is its limited bioavailability. Overall, our results suggest that oral administration of a bioavailable CUR can suppress cathelicidin and calprotectin in the joints and regulate both local (joints) and systemic (serum) inflammation, in inflammatory arthritis.Ĭurcumin (CUR) is a component of turmeric, a South-Asian spice, shown to exhibit anti-inflammatory effects. ![]() We also show a linear correlation between the abundance of these peptides in the joints with serum inflammatory cytokines TNFα, IFNγ, and MCP-1. Here, we demonstrate that daily oral administration of CUR significantly reduces the elevated levels of CRAMP and calprotectin to baseline in the joints of CIA mice. Therefore, in this study, we examined the effect CUR administration on the abundance of cathelicidin and calprotectin in the joints, in a CIA mouse model. Elevated levels of cathelicidin and calprotectin have been associated with the pathogenesis of rheumatoid arthritis. In a previous study, we have also shown that the abundance of antimicrobial host defence peptides, specifically cathelicidin (CRAMP) and calprotectin (S100A8 and S100A9), is significantly increased in the joint tissues of CIA mice. We have previously demonstrated that a highly bioavailable formulation of cucurmin, Cureit/Acumin™ (CUR), can suppress disease onset and severity, in a collagen-induced arthritis (CIA) mouse model. Curcumin, a component of the South-Asian spice turmeric, elicits anti-inflammatory functions. ![]()
0 Comments
Read More
Leave a Reply. |